Wile E. Coyote waits by his mailbox. A mail helicopter drops a package, but its parachute fails to open and it crashes onto him. He opens it to reveal a chemistry lab. He concocts some invisible paint, paints himself invisible, and waits in the middle of the road. Road Runner, unable to see him, bumps right into the coyote and knocks him off a cliff. Next, Wile E. builds a brick wall across the road and paints it invisible. Road Runner runs right through it as if it weren't there, so the coyote chases him but smacks into the invisible wall. He returns to the lab and invents a super-bouncy substance. He pours it all over himself and chases Road Runner again but misses, and bounces uncontrollably around the desert before falling off the cliff again. Finally he assembles a jet canister and propels himself into an oncoming train.
- This is the first of three DePatie-Freleng Looney Tunes to use a few Hanna-Barbera sound effects, the other two being "Sugar and Spies", and "Daffy's Diner".
- This cartoon was Rudy Larriva's final time directing a Road Runner cartoon, though he did go on to direct the last three cartoons of the DePatie-Freleng era.