She is featured as Daffy Duck's blonde girlfriend in several cartoon shorts but is only referred to as Melissa in one, "The Scarlet Pumpernickel". Melissa seems to be more than aware of Daffy's extreme faults but loves him all the same. Proving love is indeed blind.
In "The Duxorcist", Daffy is called in to rid the ghosts in her apartment. Upon getting a good look at her, Daffy falls head over heels in loves with her and the second he kisses her the feelings mutual for Melissa as hearts appear in her eyes.
Melissa Duck was the inspiration for the Shirley the Loon character on Tiny Toon Adventures (a spin-off series which follows the adventures of the next generation of Looney Tunes), though Melissa never featured in an episode of that show.
Melissa Duck's most notable role is from the series Baby Looney Tunes, which casts the adult characters from the original Looney Tunes theatrical shorts as their infant selves. Melissa had a crush on Daffy Duck ever since she was an infant. In Baby Looney Tunes, Melissa, a yellow duckling with darker hair than her adult self, acts as a comedian and enjoys making her friends laugh, even though her humor sometimes gets her into trouble.
- "Nasty Quacks" (Prototype debut) (1945)
- "The Scarlet Pumpernickel" (first official appearance/first identified as Melissa Duck) (1950)
- "Muscle Tussle" (1953)
- "The Duxorcist" (a Daffy Duck's Quackbusters cartoon) (1987)
- Bugs vs. Daffy: Battle of the Music Video Stars (1988)
- Baby Looney Tunes (baby version) (2002-2005)