Red Riding Hood is off to see her grandmother who lives in a house in the woods. The present she plans to bring her grandmother is Tweety in his cage. Sylvester sees Red's cargo and immediately follows her, his primary interest being Tweety. Red boards the bus, but Sylvester continues after her as it drives into the woods, the inattentive puddy striking a road sign along the way.
In the woods, the Big Bad Wolf waits for Red to come by, signs announcing who he is, much to Big Bad's disgust. Sylvester overhears the requisite exchange of Big Bad asking Red where she is headed and soon joins Big Bad in trying to reach Granny's house first.
Big Bad ousts Granny from the house, to which she immediately swears revenge. Big Bad and Sylvester hurriedly dress in Granny's clothing, anticipating Red's arrival. Big Bad takes his place in the bed, while Sylvester is shooed underneath. Once Red arrives and presents "Grandma" with Tweety, she sets it down as asked; Sylvester immediately approaches the cage, prompting Tweety to ask, "Hewwo, Wittle Wed Widing Hood's Gwandma! Whatcha doin' under da' bed?" After the signature exchange ending with "The better to see, smell, and eat you with," and each character's realization of their sworn enemy. Red says, "Eek! The Big Bad Wolf!" Tweety says, "Eek! The Big Bad Puddy Tat!" The chase begins.
After several back-and-forth chases, with Big Bad and Sylvester getting the worst end of things, Red and Tweety flee Grandmother's home and head for the nearest bus stop. Their pursuers chase after the bus and immediately board at the next stop ... only for them to be forcibly ejected by none other than Granny! "I told them, one of these days ..." Red and Tweety supply the rest of the line: "Pow! Right/wight in the kisser!"
- Jackie Gleason's character Ralph Kramden - "One of these days... Pow, right in the kisser!"
- When this cartoon was shown on ABC's The Bugs Bunny and Tweety Show, the part where the wolf beats Sylvester with a bucket (after Sylvester splashes the wolf with water from it) was cut from five times to one and a half. 
- This cartoon was used in Bugs Bunny's 3rd Movie: 1001 Rabbit Tales.
- After Granny said about getting back at both Big Bad and Sylvester, but why does she have grudges against Sylvester since she never encountered him (or met him as well)? Despite that the Bad Wolf was the one who kicked her out of her own house where she'd had developed her grudges only against him.
TV Title Cards
|1942||A Tale of Two Kitties|
|1944||Birdy and the Beast|
|1945||A Gruesome Twosome|
|1948||I Taw a Putty Tat|
|1949||Bad Ol' Putty Tat|
|1950||Home, Tweet Home • All a Bir-r-r-d • Canary Row|
|1951||Putty Tat Trouble • Room and Bird • Tweety's S.O.S. • Tweet Tweet Tweety|
|1952||Gift Wrapped • Ain't She Tweet • A Bird in a Guilty Cage|
|1953||Snow Business • Fowl Weather • Tom Tom Tomcat • A Street Cat Named Sylvester • Catty Cornered|
|1954||Dog Pounded • Muzzle Tough • Satan's Waitin'|
|1955||Sandy Claws • Tweety's Circus • Red Riding Hoodwinked • Heir-Conditioned|
|1956||Tweet and Sour • Tree Cornered Tweety • Tugboat Granny|
|1957||Tweet Zoo • Tweety and the Beanstalk • Birds Anonymous • Greedy for Tweety|
|1958||A Pizza Tweety-Pie • A Bird in a Bonnet|
|1959||Trick or Tweet • Tweet and Lovely • Tweet Dreams|
|1960||Hyde and Go Tweet • Trip for Tat|
|1961||The Rebel Without Claws • The Last Hungry Cat|
|1962||The Jet Cage|
|1964||Hawaiian Aye Aye|
|2011||I Tawt I Taw a Puddy Tat|