The title is a play on a nightclub in Boston called the Cocoanut Grove which later caught fire on November 28, 1942.
A night at Hollywood's fab-u-lous CooCoo Nut Grove restaurant. You never know who you will see, or be seen by. Master of ceremonies Ben Birdie (bandleader Ben Bernie) is accosted in the opening scene by Walter Windpipe (Walter Winchell). The short then proceeds to showcase a large number of Hollywood stars in the form of caricatures, including Katharine Hepburn (as a horse named Miss Heartburn), Jean Harlow, Bette Davis, Joe E. Brown, Hugh Herbert, W.C. Fields, Clark Gable, Groucho and Harpo Marx, Johnny Weissmuller, Mae West, Lionel and John Barrymore, Laurel and Hardy, Edward G. Robinson, Fred Astaire, and George Raft. Musical entertainments are provided by Dame Edna May Oliver as "The Lady in Red", the Dionne quintuplets (who were in reality only two years old at the time) and Helen Morgan, sitting on the piano, turning on the tears with a torch song.