Sylvester is rummaging through trash cans for food. When he doesn't find anything worth eating, he is very sad and goes to the dock. As he is sitting there, he sees a cruise boat and Tweety swinging in his cage. When Sylvester sees Tweety, he calls Tweety his breakfast and Tweety slams the port window on Sylvester's face, dropping him in the water.
Sylvester boards and goes into room 341 where Tweety is. Eventually, he gets Tweety in his hands and starts to go out, only to find Granny there at the door. She is very angry, and wanting to know what Sylvester is doing to her little bird. Sylvester chuckles nervously and gives Tweety back to Granny, with Tweety replying "Ooh, what a hypotwit." A chase ensues with Granny hitting Sylvester with her umbrella. During the chase, Granny loses her glasses and can't find them. Sylvester sees them and kicks them under the couch before Granny grabs them. Another chase starts with Sylvester chasing Tweety around the room. Soon, Tweety finds Granny's glasses under the couch and climbs on her, putting the glasses back on her. Then, Sylvester jumps into Granny and then she tries to hit Sylvester with her umbrella, but misses hitting him. Eventually, she chases him outside and throws her umbrella at Sylvester.
The cruise ship sails off with Granny and Tweety saying "Goodbye!" to everyone and Sylvester as a stowaway on a life boat with the number 13 on it.
Grannys glasses are off while both her and Tweety are resting. Sylvester finds this the perfect opportunity to try and eat Tweety, so he paints a picture of Tweety on Granny's glasses to trick her into thinking Tweety is in his cage. Sylvester opens Tweety's cage and then Tweety yells "Help!", causing Granny to be worried about Tweety. She puts her glasses on and thinks she sees Tweety, not knowing that Sylvester had painted a picture of him on her glasses. Sylvester chases Tweety onto a wire. Tweety goes across safely and Sylvester is having trouble coming across, since he is much heavier. Tweety springs the wire so that Sylvester is now with one paw hanging on the wire. With Sylvester sweating, Tweety starts doing an "Eenie, Meanie, Minie, Moe" and when he gets to Moe, Sylvester falls and splashes into the water and Tweety replys "Well, what do you know? No Moe."
Rough seas eventually make Sylvester seasick. When Tweety sees Sylvester with the face all green, he laughs and offers Sylvester something for his tummy, a nice piece of salt pork. When Sylvester sees this, he turns different colors and becomes even sicker, going to the medical room to get some seasick remedy. Cured, he chases Tweety all over the boat, eventually going into the furnace where Sylvester yells and falls into the water.
Back on the boat, Sylvester sees Tweety. To stop Sylvester from eating him, Tweety shows Sylvester a picture of a boat in the sea as he nauseatingly moves it back and forth, causing Sylvester to get seasick once again. Both Tweety and Sylvester run to the medical room. Tweety makes it there first, and fills the seasick remedy bottle with nitroglycerin. When Sylvester drinks this, he starts spitting up explosive sparks and another chase ensues with Sylvester spitting explosive sparks at Tweety. Granny finds out that she has been tricked and stops Sylvester. She then hits Sylvester with her umbrella. Tweety tells Granny to stop, but a loud explosion occurs and blows up Sylvester and Granny both. Sylvester is launched like a firework up in the air and another flash blows him up in the open skies. While Sylvester is coming to fall down and about to crash, the captain says Tweety's catchphrase "I tawt I taw a puddy tat!", and then when Sylvester comes crashing down on the captain, Tweety and Granny reply, "You did, you did see a pussy cat." with Granny in a captain's suit and Tweety with a sailor's cap. Granny blows the steam whistle, ending off the cartoon.
- When this cartoon aired on CBS, the part where Sylvester is hanging from the wire above the ship and Tweety plucks his fingers off one by one was cut.
- The ABC version of this cartoon cut the part where Sylvester runs inside the ship's furnace during his chase with Tweety and jumps out the smokestack with his rear end on fire. Also cut was the part where Sylvester corners Tweety and Tweety waves a crudely drawn picture of an ocean in his face, triggering the cat's seasickness.
- The cartoon's entire boat sequence is later used as a basis for the economical cartoon "Trip for Tat".
- Tweety's lines of dialogue "Atta girl Granny! Give him a hit in the head!" from this cartoon is later reused in the Road Runner CGI short "Flash in the Pain" in 2014.
- Tweety does the same "This Wittow Piddy" sequence from "A Tale of Two Kitties" in this cartoon, only that this time Tweety's victim is Sylvester.
- The original title to the cartoon was plastered over with a new title card when it was reissued in the 1959-64 season.
- This cartoon, "Big Top Bunny", and "Tweet Tweet Tweety" were the only three cartoons in 1951 to get the blue Color Rings with red backgrounds.
Tweety's S.O.S. on the SFX Resource
|← Room and Bird||Sylvester and Tweety Cartoons||Tweet Tweet Tweety →|
|1942||A Tale of Two Kitties|
|1944||Birdy and the Beast|
|1945||A Gruesome Twosome|
|1948||I Taw a Putty Tat|
|1949||Bad Ol' Putty Tat|
|1950||Home, Tweet Home • All a Bir-r-r-d • Canary Row|
|1951||Putty Tat Trouble • Room and Bird • Tweety's S.O.S. • Tweet Tweet Tweety|
|1952||Gift Wrapped • Ain't She Tweet • A Bird in a Guilty Cage|
|1953||Snow Business • Fowl Weather • Tom Tom Tomcat • A Street Cat Named Sylvester • Catty Cornered|
|1954||Dog Pounded • Muzzle Tough • Satan's Waitin'|
|1955||Sandy Claws • Tweety's Circus • Red Riding Hoodwinked • Heir-Conditioned|
|1956||Tweet and Sour • Tree Cornered Tweety • Tugboat Granny|
|1957||Tweet Zoo • Tweety and the Beanstalk • Birds Anonymous • Greedy for Tweety|
|1958||A Pizza Tweety-Pie • A Bird in a Bonnet|
|1959||Trick or Tweet • Tweet and Lovely • Tweet Dreams|
|1960||Hyde and Go Tweet • Trip for Tat|
|1961||The Rebel Without Claws • The Last Hungry Cat|
|1962||The Jet Cage|
|1964||Hawaiian Aye Aye|
|2011||I Tawt I Taw a Puddy Tat|