Road Runner is being chased down a roadway by Wile E. Coyote on a rocket, and the rocket's exhaust repeatedly runs into the camera during the chase, allowing the title cards to be shown. The chase begins in full force, and the Coyote gains on Road Runner, leans off the rocket slightly, and prepares to sink his utensils into Road Runner. Then the cartoon pauses for Wile E.'s Latin name (Famishius vulgaris ingenuisi), and then for Road Runner's (Birdius high-ballius). The chase continues down the road as Wile E. prepares to make his move, but before he can deliver the final blow, he hits his head on a tunnel arch as Road Runner goes through it. Road Runner and the rocket come out the other end; the bird escapes and the rocket returns toward its owner. Wile E. recovers from the jar and climbs down, but soon returns upwards when he sees the rocket coming at him. He sighs with relief and dismounts the arch, but, ironically, is hit by an ACME truck. Wile E. is pacing around a mountaintop when he runs directly into Road Runner, who beeps and causes Wile E.'s head to retract after being scared into a rock ceiling. Coyote chases after the bird through a cloud of dust, but only manages to throw himself into thin air. Road Runner alerts Coyote, who promptly suffers gravity to his annoyance. He manages to climb back up the mountain again, but no sooner does he do so than Road Runner, on another plateau, beeps again.
1. Coyote uses a see-saw and rock to attempt to launch himself towards Road Runner, but the rock breaks through the cliff's edge, and Coyote slides from the top of the board down and through the hole. He falls into almost the same spot as the first time, creating a cross of coyote imprints in the ground.
2. Coyote patches up a trampoline on the desert ground and mans a sniper rifle. He hears Road Runner's beep, but doesn't see him approaching. He turns around to find the bird is actually perched twenty feet behind him. So he turns the rifle around, but there's no space on the other side. Wile E. falls off the cliff again, and then directly busts through his trampoline.
3. Coyote has now ordered a giant rubber band and ties it around two rocks, hoping to trap Road Runner. However, it is so elastic that it pulls the two rocks together while Wile E. is still in between them.
4. Now, Wile E. lights a bunch of fireworks inside a barrel and bungee-swings the barrel out into open space above the road which Road Runner is about to pass. But the very edge of the rock that Wile E. is standing on breaks off, causing Coyote to swing directly below the barrel. As the rope begins to snap, Wile E. climbs up to escape the calamity, but fails to make it off in time. He falls to the ground and is smashed by the barrel. Now, Coyote has to escape his own security measure - a nailed-shut lid. Wile E. manages to hammer off all the nails and climb out of the barrel, then hide and wait for the explosion. However, he forgot to check the lid - the fireworks are on the lid, which Wile E. is still wearing!
5. Next, Wile E. builds a high wire structure and dons a wheel-head. He struggles to get himself balanced upside-down on top of the wire (even after Road Runner is long gone), and when he finally is able to let go of the rock, the wire snaps, sending Wile E. crashing headfirst into the ground. Then, the wire drapes over a power line while one end falls into Coyote's hole, resulting in Coyote incurring a violent electrical shock.
6. Coyote now attaches TNT to the bottom of a high bridge as he waits on the ground with the controller. Road Runner moves towards the intended target, but stops short of the bridge. The bridge detonates and the concrete falls directly upon the poor Coyote.
7. Wile E.'s last plan is to use ACME Tornado Seeds to trap Road Runner. Wile E. tests them by placing one next to a small cactus and shooting the requisite blast of water at it. The seed morphs into a tornado and sucks up the cacti as planned. Therefore, Wile E. drops a handful of seeds into the road just before Road Runner turns up. Wile E. fires his pistol, but instead of firing the seeds on the road to suck up Road Runner, it malfunctions and all the water comes out the bottom and when it lands on the jar of tornado seeds, it grows big and it makes the jar cold. The jar spin and all the words are gone and all the remaining seeds form a huge tornado that sucks up Coyote and brake the jar and takes him on the spin of his life, culminating in a journey into an army mine field. Wile E. suffers explosion after explosion as Road Runner pulls down the "That's All Folks!" end-title card like a curtain.
- On ABC, two scenes were cut:
- Wile E. Coyote getting electrocuted by the wire on which he was trying to balance his wheel-head. The scene faded to black right before the wire lands on the power lines, ending the scene just after Wile E. Coyote hits the ground (on a March 11, 2000 afternoon airing of "The Bugs Bunny and Tweety Show" on ABC, this cartoon aired with this—and the next part—unedited).
- Wile E. Coyote trying to drop a barrel rimmed with dynamite on the Road Runner, only to have the barrel crash on top of him. The edit made it appear that the barrel exploded before it could fall on Wile E. Coyote.
- CBS airings of this short cut the ending gag where the Road Runner pulls down the "That's All, Folks!" end-title card like a window shade as Wile E. Coyote gets caught in a tornado plowing through a minefield. The ABC version left this scene intact, but replaced the "That's All Folks!" card with a black screen.
- Gags #1, 2 and 5 were used in The Bugs Bunny Road-Runner Movie but some of the footage was edited for time.
- Coyote's first attempt to catch the Road Runner is shown in the Freakazoid! episode "Next Time, Phone Ahead".
Whoa, Be-Gone! on the SFX Resource